Gene Probe, Inc. has assumed further development, maintenance, and support for gene prediction software known as the GeneMark line. As these functions are not generally supported by academic units the Gene Probe Inc. role is to serve the community of molecular biologists working in comparative, functional and evolutionary genomics. Certainly, it is to the Gene Probe credit that the tools of GeneMark family are frequently cited programs in GenBank.

Over the years, a number of improvements have been made to the documentation and distribution code of these software tools. The programs now are available for download and include standard manuals and since the GeneMarkS and GeneMark ES/ET algorithms use unsupervised training no pre-computed models are necessary. However MetaGeneMark distribution includes a set of pre-computed models for metagenomic sequences.

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